Judy Greer looks like a younger Virginia Madsen, nothing odd there to me, and plenty of good. Didn't know her name until now, but recognize the image from
Arrested Development, I hope I have that right. I like women in glasses like that, BTW.
Sarah Silverman, cute girl who uses it to keep people off guard when she says shocking things in her act. I'm tired of her, plus her voice is annoying.
I think that she's really hot as long as she doesn't speak.

My favorite thing she ever did was the beginning of
Way of the Gun, sums up everything about her to me, best part of that movie. And uses a cool Stones song while doing it.
Helena Bonham Carter, fits the oddly attractive mold for me.
Ricki Lake, sometimes cute, sometimes not, but not odd to me.
JL Dreyfus - used to like her, all the way back to her SNL days, but not so much now.
Summer Glau is nice, but I was always more of a Jewel Staite fan, and there's nothing odd about her looks so she doesn't fit this thread.
And props to whoever mentioned Madchen Amick, I sat through some real crap films just because she was in them.