Yes, the first lady of Star Trek is gone. She was the first officer, Number One, in the original pilot (The Cage), but NBC thought folks wouldn't believe a woman in that role.
Gene snuck her back in with a dye-job as the Spock crazy Nurse Chapel.
In TNG she was the man crazy Mrs. Troi, mother of the ship's counselor. She also appeared as Mrs. Troi on DS9, the first woman to break through Odo's shell. I just know she had a ball wearing all those sexy outfits they put her in.
She also was the computer voice on all the series and in the movies.