Here's one that most people probably down even remember: Aliens in the Family. Curiously enough, Hayden Panettiere (Cheerleader from Heroes, Kairi's voice from Kingdom Hearts, and Dot from A Bug's Life) got her start here in a small cameo!
Oh dear Lord, I remember that one! I WISH I didn't, though.
These aren't that old, but I used to love both "Vengeance Unlimited" (The Punisher meets Bugs Bunny, played by Michael Madsen!) and "Murder One", which was kind of ahead of its time in that it stretched one central story over the course of one season. I also kind of enjoyed the Kolchak remake. All snuffed by ABC.
Does anybody remember the X-Files spinoff? I think it was called "Lone Gunmen" That one should've had a built-in audience but nobody seemed to care.
And I swear I can remember this truly godawful sitcom from the '90s, that was about actual Pilgrims and set 1600s America. I thought it was called "Be Thankful" or "Give Thanks" but I can't find any matches on imdb or youtube.