Based on the trailer I saw, they seem to have added some sort of plot twist about Peter Parker's past . . . something about his parents before Peter moved in with Uncle Ben and Aunt May . . . like a conspiracy theory subplot. I'm not feeling good about this.
I haven't heard what direction they're taking there. Based off what I remember of the comics, I know they at one point were in the C.I.A. and had dealings with Nick Fury and The Red Skull. But I highly doubt they're gonna attempt to tie this new film in with the continuity of the Avengers flicks that've been coming out recently.
Who knows. I do like that The Lizard's in it. And they're having a chance to deal with Gwen Stacy a bit more.
I read that they're looking to do at least a trilogy with these actors. An intersting tidbit I read: Nels Van Adder is a character in the film. From Wikipedia:
"It was revealed that soon after Norman Osborne had Stromm arrested for embezzlement, he had found only a portion of the notes detailing his partner's serum. Norman tests the incomplete version of the serum on an Oscorp employee named Nels Van Adder, driving Van Adder slowly insane and beginning his transformation into a red, demon-like being known as the "Proto-Goblin". Killing several people and blaming Norman for what has happened to him, Adder proceeds to harass and later attempts to kill him before being knocked out a window in Oscorp by Arthur and George Stacy and fleeing into the wild. In order to escape conviction for what he had done to Van Adder, Norman convinces the police that Van Adder had been experimenting on himself, and that he had secretly been trying to help him. Van Adder's current fate remains unrevealed.[1]
As well as endowing Adder with super strength and agility, the Goblin Serum also gave him large claws, talons, fangs, glowing green eyes, and near impenetrable skin (capable of withstanding several close range bullet shots)."
Now, I don't know why Adder's in the movie and Norm Osborne isn't, but whatever.