The Most Disturbing Movie?

[Francesco Dellamorte]

It's been a while since I have seen it, but Cannibal Holocaust was depressing.

Martyrs is one that hasn't been mentioned.

[snowman]

10 to Midnight (1983) about a serial killer murdering young women, with Charles Bronson as the police officer trying to bring him to justice. Lots of female nudity, which I normally don't have a problem with, but in this case the combination of nudity and the killing of young women was a big turn-off.