The one I remember was posted in a thread about the movie 300. It had the guys in the comic going to see that film and one says to another, "Wow, that was a good movie, but can you imagine anyone acting THAT over the top in real life?"
When suddenly, his friend (who's standing behind them) spills his drink all over them screaming, 'This is SODA!!!"
Next panel they're in the car and the guy yells from the backseat, "Tonight, we dine at APPLEBEES!"
Hehe.