Devastating insults?

[Trevor]

"Talk to me about an ambush? Huh? I ambushed you with a cup of coffee!" 
~ Robert De Niro to Sean Bean in Ronin.

"Yo mamma so hairy, the only language she speaks is Wookie!" 
~ Sean Maguire in Meet The Spartans.

"Hey, crotch rot! You wanna slurp my lifer's juice outta my own cup?"
~ Arlen Dean Snyder in Heartbreak Ridge.

[Doggett]

"You're nothing but an unstable, short chained molecule." - Egon

"You have a weak elctro-chemical bond" - Ray


Ghostbusers 2

[indianasmith]

"You;re a sad, strange little man, and you have my pity."
    - Buzz Light Year in TOY STORY

[Jack]

"I'll rip out your intestines and use them for a jump rope."

The evil Hercules to Ares on an episode of Hercules:  The Legendary Journeys.

[Mr. DS]

"You;re a sad, strange little man, and you have my pity."
   - Buzz Light Year in TOY STORY

On the other end...
"YOU...ARE...A...TOOOOOOYYYYYYY...you're not the real Buzz Lightyear...you're just an action figure...you are just a child's plaything..."
Woody - Toy Story

One of my ultimate favs...
"I'll shove that bat up your @ss and turn you into a popsicle..."
Ajax - The Warriors

[LilCerberus]

"You wind-up donkey bottom biters! You wipers of other people's bottoms!"
- The Frenchman from Monty Python and the Holy Grail

[p1zl3]

"Shut that c*nt's mouth or I'll come over there and f*ckstart her head!"

--Way of the Gun



"...I'd like Frank Shirley, my boss, right here tonight... I want to tell him what a cheap, lying, no-good, rotten, fore-fleshing, low-life, snake-licking, dirt-eating, inbred, overstuffed, ignorant, blood-sucking, dog-kissing, brainless, d*ckless, hopeless, heartless, fat-@$$, bug-eyed, stiff-legged, spotty-lipped, worm-headed sack of monkey sh*t he is!"

--National Lampoon's: Christmas Vacation

[Psycho Circus]

"Who's driving this car, Stevie Wonder?"

-Die Hard

[Dennis]

Conversation between Cyrano de Bergerac and Vicomte de Valvert:

Vicomte "Your nose sir, your nose is rather large."
Cyrano   "You are too simple sir, why waste your opportunity?"
Cyrano proceeds to insult his own nose at great length, then:
Cyrano   "These are all things you could have said were you a man of letters or if you possessed an
            ounce of wit to color your discourse, but of wit you have none, not an atom, and of letters
             it requires but three to mark you down sir, they are A  S  S.......ASS!"
Vicomte  "Dolt! Insolent puppy! Jabbernowl!"
Cyrano    "How do you do? And I - Cyrano Savinien Hercule de Bergerac!"




(Jabbernowl/jobbernowl - an obsolete word for a stupid person) 

[Raffine]

A classic:

"Ho, ho, ho! Well, if it isn't fat stinking billy goat Billy Boy in poison! How art thou, thou globby bottle of cheap, stinking chip oil? Come and get one in the yarbles, if ya have any yarbles, you eunuch jelly thou!"

Alex (Malcolm McDowell) A CLOCKWORK ORANGE

[Ash]

"I bet you're the kind of guy that would f**k a person in the ass and not even have the goddamn common courtesy to give him a reach-around. I'll be watching you!"

[ghouck]

"You pompous, stuck up, snot nose, giant twerp, scumbag, f**k face, d**khead, a***ole!"

-Otto, 'A Fish Called Wanda'

[Psycho Circus]

Richard Chance after sleeping with his informant:

"Guess what? Uncle Sam don't give a s**t about your expenses. You want bread, f**k a baker."

-To Live & Die In L.A.

[metalmonster]

"You Play Ball Like A Girl!"

Ham To One Of The Jocks In The Movie THE SANDLOT




"From The Looks Of Your Teeth It Looks Like Your Mother Had An Affair With Mr ED"

Buddy Love To The Comedian In The Remake Of THE NUTTY PROFESSOR



"That Aint No Handbag You Got In Your Hand ... That's Your Ti**y!"

Cletus Klump To Granny Klump In THE NUTTY PROFESSOR II : The Klumps

[BTM]

"I don't care if you like us, cause we don't like you!  We're a bad person with an ugly heart, and we don't get give a flying f**k what you think!"
           -Romy and Michelle's High School Reunion